Tibby, Lena, Carmen, and Bridget have grown up, starting their lives on their own. And though the jeans they shared are long gone, the sisterhood is everlasting. Despite having jobs and men that they love, each knows that something is missing: the closeness that once sustained them. Carmen is a successful actress in New York, engaged to be married, but misses her friends. Lena finds solace in her art, teaching in Rhode Island, but still thinks of Kostos and the road she didn't take. Bridget lives with her long-time boyfriend, Eric, in San Francisco, and though a part of her wants to settle down, a bigger part can't seem to shed her old restlessness. Then Tibby reaches out to bridge the distance, sending the others plane tickets for a reunion that they all breathlessly await. And indeed, it will change their lives forever - but in ways that none of them could ever have expected.